Article Topic: Pantothenate Kinase-Associated Neurodegeneration (PKAN) Author: Jana Warde Editor: Odette El Ghawi, Joseph Akiki Reviewer: Ethar Hazaimeh Keywords: Pantothenate Kinase-Associated Neurodegeneration, Pantothenate Kinase 2, Eye-of-the-Tiger sign, globus pallidus, basal ganglia Abbreviations: Pantothenate Kinase-Associated Neurodegeneration (PKAN), Neurodegeneration with Brain Iron Accumulation (NBIA), Magnetic Resonance Imaging (MRI), T2-weighted MRI (T2-MRI), Pantothenate Kinase 2 (PANK2), Deep Brain Stimulation (DBS)   Abstract Background: Pantothenate Kinase-Associated Neurodegeneration (PKAN) is an autosomal recessive disorder caused by mutations in the PANK2 gene, leading to iron accumulation in the basal ganglia and progressive neurodegeneration. Objective: This paper reviews current knowledge on PKAN, including its genetic basis, clinical manifestations, diagnosis, and treatment options. Methods: […]