Article: Neuroleptic Malignant Syndrome Author: Reem Tayih Editor: Ihda Mahmoud Bani Khalaf , Sadeen Eid Reviewer: Ethar Hazaimeh Keywords: Neuroleptic Malignant Syndrome, Antipsychotics, Differential Diagnosis, Pathophysiology Overview Neuroleptic Malignant Syndrome (NMS) is an idiosyncratic life-threatening medical emergency that requires immediate care. (1) NMS is generally conceptualized as a disorder triggered in the brain by neuroleptic blockage of the D2 dopamine receptors in the hypothalamus and brainstem regulatory systems that in turn causes the generalized systemic hypermetabolic syndrome. (2) The most common cause of Neuroleptic Malignant Syndrome (NMS) is the use of Antipsychotic medications, more often first-generation typical Antipsychotics. The typical […]