Article Topic: Cholinergic Crisis Author: Noha El Masri Editor: Odette El Ghawi, Joseph Akiki Reviewer: Ethar Hazaimeh Abstract Cholinergic crisis is a life-threatening condition characterized by excessive stimulation of the parasympathetic nervous system, typically resulting from exposure to cholinesterase inhibitors, including those used in the treatment of myasthenia gravis, as well as organophosphates and nerve agents. This leads to the accumulation of acetylcholine at the neuromuscular junction, causing both muscarinic and nicotinic symptoms. Muscarinic effects include bradycardia, bronchoconstriction, miosis, and gastrointestinal disturbances, while nicotinic symptoms include muscle twitching, fasciculations, and respiratory muscle paralysis. Diagnosis is based on clinical assessment and […]