Article Title: Fear and Reward Circuitry: Insights from Neuroscience Author: Amani Alfdool Editor: Aseel Qandil Reviewer: Ethar Hazaimeh Keywords: Limbic system, Amygdala, Fear, Reward, Emotions Abbreviations: PFC (Prefrontal Cortex), VTA (Ventral Tegmental Area), BNST (Bed Nucleus of the Stria Terminalis), DBS (Deep Brain Stimulation), SSRIs (Selective Serotonin Reuptake Inhibitors), CeA (Central Nucleus of the Amygdala), BLA (Basolateral Complex of the Amygdala), OFC (Orbitofrontal Cortex), CRF (Corticotropin-Releasing Factor), fMRI (Functional Magnetic Resonance Imaging), GABA (Gamma-Aminobutyric Acid), PTSD (Post Traumatic Stress Disorder). Abstract After a long period of neglect, neuroscience has again recognized emotion as a crucial area of study. This renewed […]

Article Topic: Exploring the Therapeutic Aspects of Trichotillomania. Author: Amani Alfdool. Editor: Rahmeh Adel. Reviewer: Ethar Hazaimeh Keywords: Trichotillomania, Habit Reversal Training, Hair pulling, Psychocutaneous, Repetitive compulsive behavior. Abbreviation: Trichotillomania (TTM), Obsessive-Compulsive Disorder (OCD), Habit Reversal Training (HRT). Abstract Trichotillomania is a psychocutaneous condition characterized by repetitive compulsive pulling out of one’s hair, associated with hair loss and functional impairment. The pathophysiology of trichotillomania is poorly understood and is thought to involve changes in both neural activity and cognitive function. Even though trichotillomania was recently grouped with OCD in the DSM-5, treatment approaches can differ from those used to treat […]

Article Title: Zuranolone; A Novel Oral Treatment for Postpartum Depression. Author: Amani Alfdool. Editor: Rahmeh Adel. Reviewer: ُEthar Hazaimeh Keywords: Postpartum depression, Zuranolone, Brexanolone, Neuroactive steroids, gamma-aminobutyric acid, Neuromodulation, Depression. Abbreviation: Postpartum depression (PPD), major depressive disorders (MDD), gamma-aminobutyric acid type A (GABAA) receptors, positive allosteric modulators (PAMs), gamma-aminobutyric acid (GABA), selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs). Abstract Postpartum depression (PPD) is a serious concern for maternal mental health, and the relationship between a mother and her baby, potentially impacting the child’s growth and cognitive development. Various therapeutic interventions, such as pharmacotherapy, psychotherapy, neuromodulation, and hormonal therapy, among […]

Article topic: The utilization of ketamine in managing super refractory status epilepticus Author: Amani Alfdool Editor: Rahmeh Adel Reviewer: Ethar Hazaimeh Keywords: Ketamine, Super-refractory status epilepticus, Status epilepticus, Anti-seizure medications. Abbreviation: Status epilepticus (SE), Refractory Status epilepticus (RSE), Super-refractory status epilepticus (SRSE), Anti-seizure medications (ASMs), N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), γ-Aminobutyric acid type A (GABAA), Nonconvulsive status epilepticus (NCSE), Anit-epileptic drugs (AED). Abstract Status epilepticus (SE) is a critical neurological condition with a high morbidity and mortality. It occurs when the mechanisms responsible for ending seizures fail or when mechanisms that cause abnormally prolonged seizures are initiated. Immediate pharmacological therapy […]