ِArticle Topic: Highly Aggressive Multiple Sclerosis Author: Abdeljaber Tayyem Editor: Haneen Al-Abdallat, Haneen A. Banihani Reviewer:  Lobana Mahdawi Keywords: Aggressive Multiple Sclerosis, Expanded Disability Status Scale, Humanized Monoclonal Antibodies, Immunosuppressants, Induction therapy, Escalation therapy Overview Multiple sclerosis(MS) is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS). It has various clinical presentations according to the site of the central nervous system involved and is categorized according to clinical course into clinically isolated syndrome, relapsing-remitting, secondary progressive, and primary progressive according to 2013 disease course definitions (1). A subset of MS patients experience an aggressive form of the […]